James P Zacny Selected Research

Aurora Kinase A

1/2019

Phase I Study of Aurora A Kinase Inhibitor Alisertib (MLN8237) in Combination With Selective VEGFR Inhibitor Pazopanib for Therapy of Advanced Solid Tumors.

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James P Zacny Research Topics

Disease

9	Pain (Aches) 11/2013 - 01/2003
8	Miosis 01/2015 - 01/2003
7	Psychomotor Disorders 01/2012 - 01/2003
2	Neoplasms (Cancer) 01/2019 - 01/2016
2	Chronic Pain 01/2012 - 01/2012
2	Exotropia (Exophoria) 11/2003 - 01/2003
1	Thrombocytopenia (Thrombopenia) 01/2019
1	Abdominal Pain (Pain, Abdominal) 01/2019
1	Mucositis 01/2019
1	Carcinogenesis 01/2016
1	Breast Neoplasms (Breast Cancer) 01/2016
1	Triple Negative Breast Neoplasms 01/2016
1	Basal Cell Nevus Syndrome (Gorlin Syndrome) 03/2015
1	Opioid-Induced Constipation 01/2015
1	Constipation 01/2015
1	Nausea 04/2013
1	Respiratory Insufficiency (Respiratory Failure) 12/2012
1	Fibromyalgia (Fibrositis) 01/2012
1	Spasm (Spasms) 11/2011
1	Anxiety Disorders (Anxiety Disorder) 04/2011
1	Opioid-Related Disorders (Opiate Addiction) 04/2011
1	Cough 01/2003

Drug/Important Bio-Agent (IBA)

11	Opioid Analgesics (Opioids)IBA 01/2015 - 01/2003
6	Oxycodone (Oxycontin)FDA LinkGeneric 04/2013 - 11/2003
5	Morphine (MS Contin)FDA LinkGeneric 01/2015 - 01/2003
3	Lorazepam (Ativan)FDA LinkGeneric 11/2005 - 01/2003
2	Carisoprodol (Soma)FDA LinkGeneric 01/2012 - 11/2011
2	Opiate AlkaloidsIBA 04/2009 - 01/2008
2	Hydrocodone (Dihydrocodeinone)FDA LinkGeneric 05/2008 - 01/2003
1	pazopanib FDA Link 01/2019
1	Transaminases (Aminotransferases)IBA 01/2019
1	MLN 8237IBA 01/2019
1	Aurora Kinase AIBA 01/2019
1	Estrogen ReceptorsIBA 01/2016
1	Forkhead Box Protein M1IBA 01/2016
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 01/2016
1	Transcription Factors (Transcription Factor)IBA 01/2016
1	human ERBB2 proteinIBA 01/2016
1	Phenobarbital (Luminal)FDA Link 01/2016
1	ErbB Receptors (EGF Receptor)IBA 01/2016
1	HhAntag691IBA 03/2015
1	methylnaltrexone FDA Link 01/2015
1	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2015
1	Analgesics (Analgesic Drugs)IBA 11/2013
1	Pregabalin (Lyrica)FDA Link 01/2012
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2012
1	Neuromuscular Agents (Skeletal Muscle Relaxants)IBA 01/2012
1	Acetaminophen (Paracetamol)FDA LinkGeneric 05/2008
1	oxycodone-acetaminophen (Percocet)FDA LinkGeneric 05/2008
1	Sevoflurane (Ultane)FDA LinkGeneric 04/2008
1	Tramadol (K315)FDA LinkGeneric 11/2005
1	MioticsIBA 11/2005
1	Illicit Drugs (Recreational Drugs)IBA 11/2005
1	Dextropropoxyphene (Darvon)FDA LinkGeneric 02/2004
1	homatropineIBA 01/2003

Therapy/Procedure

3	Therapeutics 01/2019 - 01/2012
2	Analgesia 01/2008 - 08/2004
1	Palliative Care (Palliative Therapy) 01/2015